The purpose of this study was to synthesise and characterise nanoparticles containing extract from the medicinal herb Dolichandrone falcata, which has been shown to have antiulcer capabilities. Dolichandrone falcata was used in the study to extract bioactive chemicals, which were then processed through an optimised process to create nanoparticles. The size, shape, and stability of the nanoparticles were examined using a variety of characterisation methods, such as Zeta sizer, scanning electron microscopy, and transmission electron microscopy. The produced nanoparticles (NF1) showed a particle size range of 1 to 130 nm, with a mean size of 94.3 nm, according to the data. Zeta potential studies showed that the nanoparticles were stable, with a value of -26.8 mV. Images from scanning electron microscopy showed spherical nanoparticles with a consistent size distribution. The Dolichandrone falcata extract was successfully encapsulated by the nanoparticles, as evidenced by their 82.56% entrapment efficiency. Using a lyophilization procedure, the synthesised nanoparticles were then used to create nanoparticulate tablets (F1-F5). Angle of repose, bulk density, tapped density, Carr's index, Hausner's ratio, weight fluctuation, thickness, hardness, friability, and dissolving profiles were among the pre- and post-compression characteristics of these tablets that were methodically assessed. The tablets demonstrated excellent flow characteristics, suitable hardness, low friability, and reliable drug release patterns in acidic environments, indicating that they may be used orally. A pyloric ligation-induced ulcer model was also used to evaluate the antiulcer activity of the nanoparticles loaded with Dolichandrone falcata extract. In comparison to the control group, the animals treated with the extract-loaded nanoparticles showed a significant decrease in ulcer index, a significant reduction in stomach volume and acidity, and an elevation in gastric pH. Standard medication ranitidine showed comparable efficacy in preventing the development of ulcers. With an astounding 81.22% inhibition rate, the extract-loaded nanoparticles demonstrated their exceptional antiulcer efficacy. The safety of the Dolichandrone falcata extract was further supported by acute toxicity testing, which made it possible to determine the right dosages for further research