Idiopathic pulmonary fibrosis (IPF) is an insidious interstitial lung disease that involves extensive deposition of fibrotic tissue within the lungs. IPF continues to have a significant negative impact on patients’ survival despite expansion of treatment modalities, the genetic and genomic basis mechanisms that cause IPF remain largely ill-defined. Objective: The primary objectives of this study are to describe the genetic variations and genomic alterations implicated in idiopathic pulmonary fibrosis while also outlining possible points of intervention. Results: Analysis of the genetic data comprising 9 COPD patients along with 500 IPF patients suggested a significant association between specific single nucleotide polymorphisms... Discussion: This study's findings illustrate the contribution of inherited characteristics to the risk of IPF development, indicating possible wide applications of molecular medicine in clinical settings. A deeper understanding of the molecular basis of IPF is expected to provide productive avenues of newer diagnostic as well as therapeutic measures for the disease.