This study aimed to conduct a histological analysis of the kidney after experimental infection with klebsiella pneumoniae. K. pneumonia isolates obtained from master's students at Baghdad University in Iraq. Twenty rats were utilized as test subjects in this experiment. Their weight varied from 160 to 220 g, and their ages were between 2 and 2.5 months. Two groups of rats were used: Group A (10 rats) were given normal saline suspension as the control treatment. Group B: 10 rats underwent infection with 0.2 cc of K. pneumonia suspension orally. Animals were slaughtered, their kidney tissues were stored in 10% formalin for histopathological preparation after 7 and 14 days of infection, and the prepared slides were stained by hematoxylin and eosin. Kidney regions had substantial acute inflammatory alterations shortly after an infection, including dilated and blood-filled B.Vs, the presence of fibrin, edematous fluid in the interstitial tissues, neutrophilic infiltration, and liquefactive necrosis after seven days. At 14 days post-infection, significant histopathologic abnormalities included less vascular congestion, fibrinous exudate with PMN infiltration, and a lack of lymphocytes. In conclusion, K. pneumoniae can cause different pathological lesions in the kidneys of rats, such as necrosis and congestion of blood vessels as well as glomerulonephritis.