Free radicals in cigarette smoke contain compound that are harmful to your health. Diabetics have high levels of oxidative stress due to excessive free radicals and lack of antioxidants, so they need antioxidants for free antioxidants in the body. We show that some herbal biofilters have the ability to scavenge free radicals in cigarette smoke. This is for the immediate effect of exposure. The sample for this study used seven treatment groups that had previously induced diabetes with streptozotocin. Exposure to cigarette smoke was carried out for 3 weeks and blood glucose was checked every week. The mice were then dissected and the histological picture of the pancreas was observed. Statistical results using OneWayAnova show that exposed to cigarette smoke using a biofilter made from herbs affects blood glucose levels and histology in diabetics.