Breast cancer is the major cause of death among women worldwide. For the sake of precision medicine, and since molecular subtyping of breast cancer is important to individualize its management, to understand prognosis of disease and avoid overtreatment, the gold standard for breast cancer management became the characterization of breast cancer molecular subtypes. Objectives: The present study aimed to detect the correlation between describe Mammogram and Ultrasound morphological features and in different molecular subtypes of breast cancer. Methods: A cross-sectional study conducted on all patients (227 in total) who were referred to the Radiology Department –at Ain-Shams University Hospital presented with breast lumps and /or bloody nipple discharge, patients with benign findings were excluded and all suspicious patients were biopsied and all biopsies received histopathology with immunohistochemistry until a sample size of 100 patients were achieved