Cancer affects people's life, poses a threat to world health, and has a number of negative side effects when treated. Both industrialized and developing nations struggle with a significant public health burden from cancer. The body's abnormal expansion of cells increases the chance of suffering from a tumor and the number of cancer patients worldwide is rising daily. The resistance of cancer cells to currently available treatments encouraged the quest for novel anticancer drugs. Pyridine, a preferred scaffold, is a component of living things and is important for many biological processes as well as the development of cancer. It is regarded as an important molecule in the therapy of cancer because of its structural similarities to the nucleotide base pair of DNA and RNA. Main text: Many novel pyridine derivatives have been designed and developed for their anticancer activity within the previous few years. Many novel pyridine compounds have been created recently, and their potential anticancer properties have been investigated which includes Biological evaluation, QSAR and Molecular docking. Conclusion: This review aims to aid in the creation of pyridine scaffold-based anticancer medications that are more effective and potent. This review article describes the Imidazopyridine ring's anticancer activity that has been noted in several different cancer cell lines. It will be helpful in directing researchers worldwide who are working on this moiety will be vital to the advancement of the chemistry of imidazopyridines