Background: Breast cancer is a prevalent disease that significantly impacts physical, emotional, and social well-being. Assessing and improving the quality of life (QoL) of patients during and after treatment is increasingly recognized as vital. Methods: A mixed-methods approach combining quantitative (EORTC QLQ- C30, QLQ-BR23) and qualitative (semi-structured interviews) data was used. The study was conducted at a hospital, examining breast cancer patients at various stages of treatment. Results: Quantitative findings showed QoL decline during treatment, particularly in physical, emotional, and social functioning. Qualitative data revealed issues like psychological distress, body image concerns, and the importance of social support. Discussion: Breast cancer treatment substantially impacts QoL, with physical limitations and psychological distress being common challenges. Post-treatment recovery in some areas highlights the importance of addressing both medical and psychosocial needs. Conclusion: The study emphasizes the need for comprehensive, patient- centered care, addressing both physical and emotional aspects of life. Post- treatment rehabilitation and ongoing support are crucial for improving overall QoL in breast cancer survivors.