Ayurvedic plants hold promise for drug discovery as they are rich in bioactive phytochemicals. Bacopa monnieri (BM) is one of these plants that has been used to treat cognitive impairments (CI). Therefore, this study evaluates the pharmacological impact of the saponins found in BM on CI using in-silico approach. 32 saponins from BM were examined for ADMET. Their targets were predicted, out of 217 targets 13 were found to be involved in CI. These were further analyzed using pathway enrichment, docking and simulation tools. It was observed that some of the saponins had good affinity for SCN2A and DNMT1. Further Molecular Dynamics simulation for 100 ns shows the stability of complex. These two proteins are known to play crucial role in development of CI. The findings represent a significant step towards understanding the medicinal properties of BM which may be the potential drug candidates for the treatment of CI.