Thiazoles and fused heterocyclic thiazole derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activities. Thiazoles and their derivatives exhibit a wide variety of biological activities like antidiabetic, anti-inflammatory, anti-convulsant etc. Special attention is warranted towards the synthetic design and development of Thiazoles because of their high demand in academic and pharmaceutical sectors. Keeping in view of the biological importance of Thiazoles, in the present work, we have planned to synthesize some novel Thiazoles, to characterize them by using TLC and IR and to evaluate them for in-silico antiosteoporosis activity. The structures of these synthesized compounds were confirmed by IR. All the values and results of this spectral and elemental analysis are found to be in the normal range. These compounds can be further exploited to get the lead compound.