Introduction: Adults are the target group for drug dependence research because of their rising rate of substance abuse, complex social and environmental influences, and significant impact on public health and societal well-being, making understanding and addressing their drug-related issues crucial for intervention and policy development. The objective of this study was to examine the Attitudes and Practices of Drug Dependence Among Adults in Abha City. Methods: This study used a cross-sectional design, with 643 adults chosen using a convenience sample method from Saudi Arabia's Abha city. Demographic variables of adults, substance abuse attitude survey, and practices of drug use survey. The variables were measured using a questionnaire. Information was gathered using the Google Forms survey, which was collected from August through October 2023. Data were analyzed using t-tests and chi-square tests. Results: There was a significant difference in the mean attitude and practice scores of male and female adults (p<.001); however, there was no correlation (r=0.025) between the attitude and practice scores of drug use among adults (p< 0.05). Age, gender, marital status, and educational status of adults were associated with attitude and practice scores (p<0.05). Adult family type was associated with attitude scores (p<0.05), whereas it was not associated with practice scores (p>0.05). The area of residence of the adults was not associated with attitude scores (p>0.05) but was associated with practice scores (p<0.05).