Introduction: With its ability to fight infections and inflammation, propolis extract might improve dental materials. This work looks at how dental pulp capping materials respond to Pakistani propolis extract. Materials and Methods: Using ethanol, propolis was taken out of Pakistani honeybee colonies and added to calcium hydroxide and mineral trioxide aggregate (MTA) in different quantities. The extract underwent GC-MS analysis. We assessed compressive strength and setting time. Surface morphology was examined with scanning electron microscopy (SEM). We measured the antibacterial activity by disc diffusion. Testing for cytotoxicity involved methyl thiazolyl tetrazolium (MTT) tests. Anti-inflammatory effects were assessed by ELISA-based cytokine production in macrophage cultures. Tukey's HSD tests and an ANOVA were used to analyse the data. Results: Major bioactive substances were present in the propolis extract. Increased propolis concentrations prolonged setting periods and improved MTA and calcium hydroxide compressive strength. Significant improvement was made in antibacterial action. Acceptable cell survival persisted, and lower cytokine levels suggested anti inflammatory effects. Conclusion: Even with longer setting times, Pakistani propolis extract improves compressive strength, antibacterial activity, and biocompatibility of dental pulp capping materials. Potential for new restorative dentistry therapies is suggested by its anti-inflammatory qualities, which may help pulp tissue repair. Clinical validation and more research are advised.