Diseases of the oral mucosa (COPD), which is associated not only with the tendency of aging of the population, general somatic diseases, the presence of bad habits, environmental degradation, but also with the spread of systemic diseases that manifest themselves on the oral mucosa. The prevalence of COPD diseases among the Russian population varies from 3% to 20%. Many diseases of COPD have a chronic course, and with inadequate diagnosis and treatment, they tend to malignancy. Malignant neoplasms (ZNO) of the SOPR are a severe pathology of the maxillofacial region, which affects the quality of life of patients [2].