ISSN : 2663-2187

JASMINUM GRANDIFLORUM LINN. ROOTS' EFFECTS IN GASTRIC MUCOSAL ULCERS

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Parth Kumar, Kuldeep Singh, Manoj Kumar Mishra , Priyansu Yadav
ยป doi: 10.48047/AFJBS.6. si2.2024. 5841-5847

Abstract

In traditional medicine, Jasminum grandiflorum L. (Family: Oleaceae) is used to treat ulcerative stomatitis, skin conditions, wounds, and ulcers. The hydroalcoholic extract of Jasminum grandiflorum L. root was tested for its anti-ulcer properties using albino mice that were given acute stomach ulcer models created by pylorus ligation and ethanol. To evaluate the antiulcer efficacy, researchers examined the effects of an oral root extract of JG L. (100 & 200 milligram/kg) on the amount of gastric juice, free acid, gastric pH, total acid, and ulcers caused in pylorus ligated mice. Compared to the conventional medicine ranitidine (50 mg/kg), there was a substantial (P < 00.01) reduction in the ulcerative lesion indices that is dose-dependent created by Eth. + pyloric ligation induced acute gastric ulcer models in albino mice. Mice's stomach fluid pH increased, free acid, total acid, and gastric fluid volume decreased, all indicating the anti-secretory and perhaps anti-ulcer effects of JG L. root.

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