In the recent past, there has been an increasing trend in the usage of biologic agents in systemic immune mediated diseases like rheumatoid arthritis, psoriasis, inflammatory bowel diseases and in certain types of cancers. Due to an increased understanding of disease pathogenesis, BAs are used nowadays in the management of several immune mediated oral disorders like oral lichen planus, oral pemphigus vulgaris, mucous membrane pemphigoid, Bechet’s disease, Sjogren’s syndrome and Orofacial granulomatosis. The aim of the study is to assess the knowledge and create awareness about usage of biologic agents in management of oral mucosal disorders among dental students. A questionnaire survey was conducted among dental students of a private dental college and hospital in Chennai. When asked about usage of biologic agents in oral mucosal disorders only 69% had responded yes. Only 51% had responded that biologic agents are used in the management of oral mucosal diseases like oral lichen planus, pemphigus vulgaris and recurrent aphthous stomatitis. When asked about whether knowledge on biologic agents is essential for dentists, 91% responded yes. Our study findings show that awareness on usage of biologic agents among dental students is not adequate. The dental professionals should be aware about the usage, directions, dosage and possible adverse effects of biologic agents in management of oral mucosal lesions.