The most current methods for controlling diseases spread by mosquitoes involve methods that kill larvae at vector rearing facilities on a big scale. Therefore, the current research was to carry out the phytochemical analysis of plant extracts from Artemisia pallens leaves and Crossandra infundibuliformis flowers in both aqueous and organic solvents to assess the larvicidal properties of these extracts on third-instar larvae of the dengue fever-causing mosquito Aedes aegypti. According to the phytochemical study, flavonoids, alkaloids, anthraquinones, and tannins were present in both extracts. The mortality percentage of larvae and larvicidal efficiency assay revealed that the acetone fraction of the A. pallens and C. infundibuliformis plant extract (500 ppm concentration) was the most active, with LC50 and LC90 values of 187.54 ppm and 871.22 ppm; respectively which was in contrast to the hexane fraction (LC50 = 307.65 and LC90 = 2472 ppm respectively). The plant extracts of A. pallens and C. infundibuliformis in synergistic combination had the greatest larvicidal potential in the following order acetone > hexane > aqueous extract. The findings imply that the extract of the herb A. pallens and the extract of C. infundibuliformis may be effective larvicidal agents against Ae. aegypti and demand further investigation as mosquito control agents.