Background: Enhancing medication adherence among middle-aged and elderly patients who have undergone coronary artery bypass graft surgery is essential for achieving improved health outcomes. Ensuring that these patients consistently follow their prescribed medication regimens can significantly impact their recovery and overall well-being. Aim: To evaluate medication adherence among patients following coronary artery bypass graft (CABG) surgery and to develop strategies for enhancing adherence to prescribed medications in this patient population. Methodology: A prospective interventional study was carried out in the cardiothoracic and vascular surgery department, involving 110 post-CABG (coronary artery bypass grafting) patients who provided informed consent. Initially, a questionnaire was administered to evaluate their medication adherence, and tools to enhance adherence were provided. At the final visit, the same questionnaire was used to reassess adherence levels, along with evaluating parameters such as blood sugar levels, blood pressure, and ejection fraction (via ECHO). Results: The study results indicated that 94% of patients exhibited improved medication adherence by the final visit. Additionally, there was a significant improvement in the ejection fraction (EF) rate. By the final visit, patients showed enhanced blood pressure, blood sugar levels, and heart rates. Conclusion: Pharmacist counseling significantly enhanced patients' knowledge, attitudes, and behaviors. This study demonstrates that pharmacist care positively impacts mortality and morbidity in post-CABG surgery patients. In middle-aged to older adults, adherence to medication is crucial for achieving better health outcomes.