BACKGROUND: Adolescence is a critical phase of human development, characterized by physical, emotional and psychological changes. Rapid cultural changes increase adolescent adjustment problems, which can lead to severe psychological issues like depression, anxiety and stress. Adjustment is a dynamic process influencing adolescent development. MATERIALS AND METHODS: This study analysed 206 school-age adolescents, including both genders, using purposive sampling. Tools used were General Health Questionnaire, EPOCH Measures of Adolescent Well-Being, Depression Anxiety and Stress Scale for Youth and Adjustment Inventory for School Students. RESULT: The results indicate girls have higher perseverance and connectivity, while boys show superior engagement, optimism and happiness. However, girls experience higher stress, anxiety and depression. Both genders show good emotional adjustment, with girls receiving more social support and boys receiving more academic assistance. Higher levels of psychological distress are linked to more severe symptoms of depression, anxiety and stress. CONCLUSION: These results highlight the relation among mental health conditions and adjustment challenges among adolescents, highlighting the importance of addressing social and emotional aspects in fostering adolescent well-being and academic achievement.