Benzimidazole derivatives have played an essential role in the field of medicinal chemistry since decades. They are reported to possess a broad spectrum of activities of immense therapeutic potential. In the present study an attempt has been made to synthesize various benzimidazole derivatives through Microwave assisted reaction. In order to predict the probability of the active compounds for being therapeutically active, molecular docking, ADMET and adverse effect studies were performed. The compounds had appropriate ADMET values which suggests that these derivatives are likely to have drug-like property with a good safety profile. The synthesized compounds were characterized by IR, 1H and 13C NMR spectroscopy, LC-MS and Elemental analysis and screened for in-vitro anthelmintic, antioxidant and anticoagulant activities. The experimental observation enables the newly generated Benzimidazole derivatives to be attractive candidates as anthelmintic, antioxidant and anticoagulant agents