Drugs intended for treating various neuro-degenerative disorders possess significant challenge in crossing the Blood Brain Barrier (BBB) & reaching the site of action. As conventional drug delivery has not been successful in meeting the demands, the focus has been shifted to a novel delivery approach. Out of various delivery approaches, lipid based delivery systems proved to enhance the efficacy of drugs by crossing BBB and reaching target site by enhancing solubility, permeability and bioavailability. Hence in the present chapter the authors focused on various lipid-based drug delivery strategies like nanoemulsions, solid lipid nanoparticles and liposomes on Parkinsonism, Huntington’s disease, Epilepsy and Alzheimers neuro-degenerative disorders. The chapter also highlighted few examples related to design of experiments & artificial neural networks.