Liver cancer is the malignancy that causes the most fatalities globally and ranks sixth in the US amongst all other cancers. Liver cancer has a dismal prognosis since patients frequently receive their diagnosis after it is already in an advanced stage. Utilizing natural substances may offer patients greater results with less systemic toxicity and adverse effects. Studies on the epidemiology of cancer revealed a link between frequent eating of a high fibre, low fat diet and considerable amounts of fruits and vegetables with a potential reduction in overall cancer risks. Potential dietary natural items including grapes, plums, pomegranate, tomatoes, garlic, ginger, etc may be able to prevent or treat liver cancer by shielding the liver from carcinogens, obstructing metastasis and tumor cell proliferation, or even by enhancing the effectiveness of chemotherapeutic medicines. In this review, we outlined the epidemiologic data on food and the potential for treating and preventing liver cancer