Research from both retrospective and prospective clinical investigations has shown that prenatal VPA exposure can cause signs of autism spectrum disorder (ASD) in children, including social impairment, communication impairments, anxiety, obsessive/repetitive behaviour, and impaired motor abilities. Bipolar illness, migraine, and epilepsy are all treated with valproic acid (VPA), an anti-epileptic medication. As an inhibitor of histone deacetylases and an epigenetic modulator, VPA is a powerful teratogen for the progeny of human females undergoing pregnancy. The teratogenicity of VPA revealed foetal valproate syndrome, a condition in which offspring have characteristics of autism spectrum disorder (ASD), dysmorphic features, cardiac abnormalities, neural tube malformations, and neurodevelopmental delay. Omega-3 is polyunsaturated fatty acids (PUFAs). They are present in seafood like krill and algae as well as fish. These polyunsaturated fatty acids (PUFAs), which are found in membrane phospholipids. For some high-fat tissues, such as brain and retinal tissue, OM3FAs have a stabilizing and protective impact. Because docosahexaenoic acid (DHA) is a crucial component of the brain's phospholipid membranes, OM3FAs capacity to preserve the cell membrane integrity of neural tissues improves cognitive function, Alzheimer disease, and dementia. There for, Omega-3 protects against Valproic acid