Alzheimer's disease is an age old disorder occurs due to loss of neurons. It is characterized by the loss of cognitive and motor skills, memory loss and behavioral changes. The currently available FDA approved pharmacological treatments are very limited and offer only symptomatic relief. Simultaneously, they are also associated with adverse effects. Current study aimed to evaluate the nootropic potential of the 50% hydroalcoholic extract of Adiantum capillus-veneris, and its isolated compound quercetin against scopolamine induced amnesia in Wistar rats using MWM and rotarod tests. The study is designed to assess the effects of the extract and quercetin on spatial learning and memory and motor functions. Biochemical analysis quantified the levels of acetylcholinesterase markers of oxidative stress and neuroinflammation in the rat brain. Treatments significantly improved the spatial memory and motor performance by restoring the altered biochemical parameters compared to the control. The findings support the potential of A. capillus-veneris as a therapeutic agent for cognitive enhancement and neuroprotection, highlighting its role in managing Alzheimer's disease. This can overcome the rate limiting factor of drug failure in the drug development pipe-line as it act by multi-model-mechanisms. Further research is needed to validate the mechanisms underlying these effects and to assess the clinical applicability of this herbal remedy.