OCT can play an important role in monitoring the disease and process ing of papilledema. Following the peripapillary RNFL thickness over different visits provides a quantitative and sensitive measurement of changes in the papilledema. While the Frisén grading scale for clinical papilledema ranges from grade I to V, the peripapillary RNFL thickness can range from 50 µm to over 500 µm giving it a much larger dynamic range to objectively evaluate for change. In addition, there is significant variability among experts in grading papilledema based on the Frisén scale, and therefore the peripapillary RNFL is easier to follow objectively for change, especially when the patient is seen by different care providers. A decrease in peripapillary RNFL thickness in can be either a result of improving papilledema or increase in axonal loss from disease progression. Combining the macular GCIP thickness with the peripapillary RNFL thickness allows one to evaluate for optic neuropathy in the presence of papilledema.