Targeted drug delivery with biodegradable polymer-based implants presents a novel approach to treating a variety of diseases, including cancer, chronic illnesses, and post-operative problems. These implants offer a number of benefits over traditional drug delivery techniques, including the ability to precisely target, regulate, and prolong the release of therapeutic medicines at the site of action. This minimizes side effects, enhances drug absorption and lowers systemic exposure. A full understanding of the interplay between the geometry of the implant, the characteristics of the drug and the polymer is important to optimise these implants. In the present work, Clotrimazole loaded implantable system for localized infections. Chitosan was used as a biodegradable polymer, and sunflower oil worked as an exterior phase. The I-optimal design was employed for optimizing the process parameters. The drug release at 12 h and on the 10th day was picked as a response. At 12 hours and 10 days, the optimized formulation demonstrated 5.531% and 97.99% release, respectively. The particle size of the prepared implantable formulation was found to be 15.35 ± 6.29 µm with a PDI of 2.45. The optimized formulation demonstrated prolonged medication release, it was concluded.