Aim: The study focuses on enhancing the solubility and dissolution rate of Lansoprazole, a BCS class II drug with low solubility and high permeability. Methodology: Various solid dispersion techniques, including solvent evaporation, melting/fusion, and solvent-melt methods, were employed using different hydrophilic carriers such as PEG 4000, PEG 6000, and PEG 8000 (in various drug, carrier ratio i.e., 1:2, 1:4, 1:6). The physical mixtures and solid dispersions were prepared and analyzed for drug content, aqueous solubility, and in vitro dissolution. FTIR spectroscopy and X-ray diffraction studies were conducted to investigate potential interactions and crystalline changes. Results: Results demonstrated significant improvements in solubility and dissolution rates for the solid dispersions compared to the pure drug. Among the techniques, the solvent-melt method showed the most substantial enhancement in dissolution rate, attributed to molecular-level dispersion of the drug and improved wetting and solubility characteristics. Invitro dissolution studies revealed that 6SMSD3 solid dispersion prepared by solvent melt method with PEG 6000 in 1:6 (drug: carrier) ratio gives better release than other formulations. As a result, endeavors have been initiated to improve the solubility of Lansoprazole using the solid dispersion technique, aiming to develop fast-disintegrating tablets. The optimized solid dispersion (6SMSD3) were further developed to fast disintegrating tablets (F1 to F10)using different super disintegrants (SSG, CP,CCS) at various proportions. From the developed ten formulations, F10 showed higher 82.31% drug release at the end of 60 minutes than other tablets formulations and pure drug which might be due to the use of super-disintegrant (CCS) which absorb the medium and swells when exposed to dissolution medium and promote the rapid disintegration of tablets and also MCC and Mannitol prevent the aggregation of solid dispersion particles by coating on them and increase the absorption of dissolution medium and promote the faster disintegration. Conclusion: Hence, the findings suggest that solid dispersion is a viable strategy for enhancing the solubility and bioavailability of poorly soluble drugs like Lansoprazole.