Aim: This study investigated the impact of orthodontic treatment on sleep quality in patients with malocclusion. Methodology: Utilizing a prospective cohort design, we assessed changes in sleep patterns and quality before and after treatment in 100 patients with various types of malocclusion. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI), while sleep duration and efficiency were monitored through sleep diaries and actigraphy. Result: Results indicated significant improvements in PSQI scores, sleep duration, and sleep efficiency over six months and one year. Patients with Class II malocclusion and those using clear aligners experienced particularly favorable outcomes. Conclusion: The study suggests that orthodontic treatment positively impacts sleep quality, though limitations such as the absence of a control group and reliance on self-reported measures must be considered.