Background: The 70:70 paradox limits access to healthcare in India: people incur 70% of their healthcare expenses out of their pockets, of which 70% of the amount goes only toward medications, leaving them in debt and impoverished. Some of India's main health obstacles are high out-of-pocket expenses (OOPE), inadequate or ambiguous quality of medical care, restricted access, and lack of proper medical care availability. It was discovered that bibliometric evaluation of scientific articles about OOPE on health is lacking, even though various academics have generated multiple research publications emphasizing the role that healthcare plays in bolstering the health systems. Methodology: The available literature was thoroughly reviewed using the PRISMA standards for systematic reviews. The Scopus database was used to collect academic literature on "Out-of-pocket healthcare expenditure" for the study since it provides wider access to relevant publications. R-studio and Vos-Viewer were both used in the study's bibliometric analysis to display visualizations and deliver clarity through the interpretation of the findings. Results: The study identified 323 sources, including journals, reviews, and other publications, and compiled a total of 858 articles by 2707 authors. The findings demonstrate that between 2003 and 2023, scholarly research on out-of-pocket expenses increased gradually, highlighting the importance of healthcare. It was found that more comprehensive research on OOP expenses on health and other topics related to health is needed to gain more knowledge to better the healthcare system, as there have been relatively few studies conducted on issues, such as poverty, income level, education, the elderly, adolescents, pregnant women, inpatients and outpatients, rural-urban regions, etc. This implies that there is further scope for research as these problems haven't been fully explored yet. Conclusion: Academic research on OOPE indicated the significance of healthcare protection for growing OOPE in the areas of healthcare spending and universal health coverage. Individuals' OOP payments for healthcare services can undermine equity and drive vulnerable groups into poverty. It's critical to lower OOPE in systems for healthcare, which is the further reason for more in-depth research in this field. Besides, providing public awareness and offering financial assistance to the population, the government must adopt a holistic approach that includes policy changes, infrastructural development, and research & development to adequately address the health challenges caused by high OOPE on health.