The maintenance of disease-free human existence on this planet has been made possible by traditional medicines, which are primarily made from plants. In this study, extracts of leaf of Grewia multiflora Juss. (Malvaceae) was pharmacotherapeutically investigated. The plant is said to be used against diabetes, liver diseases, bone fractures. Defatted residue of leaf powder was soxhlated to get chloroform, acetone, methanol and aqueous extracts in a common manner. A part of the residue obtained after chloroform extract was soxhlated with a solvent mixture methanol and water (70:30) to get the extract methanol(70). The content of methanol(70) was in excess in comparison to methanol and others. Extracts were subjected to phytochemical investigation, study for total flavonoid and phenolic contents. Methanol and methanol(70) extracts were investigated for hepatoprotective and antiantidiabetic activities. Suspension of the extract in 0.5% sodium carboxymethylcellulose was taken for investigation of hypoglycemic capability of extract on diabetic rodent by comparing with the glibenclamide. Me(70)[300mg/kg] was having excess hypoglycemic capability than Me[300mg/kg]. This activity corresponds to flavonoids and other phytochemicals in Me(70) & Me. Me(70) [300 mg/kg p.o.] due to its antioxidant properties decreased the enzyme elevation to normal in serum due to hepatic damage caused by carbon tetrachloride