The present study was aimed to evaluate the antidiabetic activity of methaolic extract of the leaves of CR on streptozotocin (STZ)-induced diabetic rats. Experimental animal was induced by a single dose of intraperitoneal injection of STZ (65mg/kg). Adult male Wister albino rats were divided into five groups; normal control, diabetic control, diabetic glibenclamide (5mg/kg), diabetic CR M. extract (200mg/kg), and diabetic CR M. extract (400 mg/kg) for 14 days and analyzed for body weight (BW) and blood glucose. The STZ-treated diabetic control rats showed a significant increase in blood glucose with a concomitant decrease in BW. Oral administration of CR M. extract (200 and 400 mg/kg) and glibenclamide (5 mg/kg) for 14 days showed a significant reduction in blood glucose levels and elevation in the body weight studies as compared to control and glibenclamide-treated rats. The results of the present study showed that a potent antidiabetic activity was present in the aerial part of plant CR M. extract