Acmella Paniculata is a small annual plant that has been used traditionally across many cultures worldwide as a food and for the treatment of many diseases and illnesses. It is a common toothache plant which belongs to the Asteraceae family growing mainly in nearby streams, rivers, fields and swamps. The herb grows up to a length of 32-60 cm and its identical characteristic of the plant is the discoidal capitula of the flowers. The whole plant is rich in many bioactive compounds that exhibit antioxidant, anti-inflammatory, anti-malarial, antibacterical, anthelmintic and local-anesthetic properties. The current reiew explores the utility of the plant for nutritional and therapeutic purposes as a natural remedy for day-to-day health issues. It describes the distribution, habitat, chemical composition, ethnomedicinal uses and pharmacological properties of the plant.