Blumea mollis has been widely used in traditional medicinal system for the cure of various diseases. It is used by people for the treatment of fever, inflammation and infections. This plant has antioxidant, cytotoxic and antibacterial property. Present study is about Blumea mollis belonging to the family Asteraceae comprises physiochemical analysis and their pharmacological efficacy. Materials and Methods: Five extracts (Pet. Ether, Ethyl acetate, chloroform, ethanolic, and aqueous) from the plants were prepared and analysed. Qualitative phytochemical tests were used to detect the presence of alkaloids, tannins, saponins, flavonoids, glycosides and phenols. Antipyretic activity was evaluated using brewer's yeast induced pyrexia model in rats. ethanolic extract were given at dose of 100, 200 and 400 mg/kg p.o. Results: The results showed that all the extracts studied contain the bioactive compounds glycosides, phenols, alkaloids, flavonoïds, tannins, saponins, except aqueous extracts of Blumea mollis. Ethanolic extract at the doses of (100, 200 and 400 mg/kg p.o.) significantly decreased the rectal temperature of the rats. Conclusion: Phytochemical analysis and their pharmacological efficacy is helpful in the standardization of drug.