ISSN : 2663-2187

PREPARATION AND EVALUATION OF OSMOTIC TABLET OF TOFACITINIB CITRATE

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Sheetal B. Gondkar, Saba R. Shaikh, Pradnya K. Gangurde, Rishikesh S. Bachhav, Nitin Hiray
ยป doi: 10.33472/AFJBS.6.13.2024.4526-4541

Abstract

The aim of this research is to create Controlled Porosity Osmotic Tablets incorporating Tofacitinib Citrate aimed at treating Rheumatoid Arthritis. These tablets operate on the principle of osmosis. Using a 32 factorial design, nine formulations were prepared. The formulation involved a wet granulation method, with the core tablet comprising osmotic agent (NaCl), release retardant (HPMC), and other excipients. A cellulose acetate coating served as the semipermeable membrane, which upon contact with aqueous fluid forms a microporous structure. The evaluation included pre compression parameters, and also post compression parameters. Also SEM analysis was done. Batch F8 exhibited a drug release of 99.80% within 24 hours. Dissolution kinetics were evaluated utilizing multiple pharmacokinetic models including Korsmeyer-Peppas, First order, Higuchi model and zero-order models across all batches.

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