This study was conducted to assess the prevalence and treatment of Oral Submucous Fibrosis in a known population. Material and methods: This study comprised of 100 subjects in a known population. The subjects had been informed about the procedure and had been asked for consent. The subjects who were willing to participate in the study and who were ready to give consent had been included in the study while those who were not willing to participate had been excluded. The subjects underwent intraoral examination. The findings were noted. Statistical analysis had been conducted using SPSS software. Results: In this study there were 100 subjects out of which 40 were females and 60 were males. OSMF was present in 17 subjects and was absent in 83 subjects. The prevalence of the condition was 17%. Conclusion: The prevalence of OSMF in this study was 17% and the treatment included dexamethasone and hyaluronidase enzyme which were injected submucosally into the fibrotic bands weekly for 6-8 weeks. Also, antioxidants like alpha lipoic acid and lycopene were commonly used as first line of treatment. Also, zinc acetate tablets for 4 months, 50 mg three times daily, and vitamin A 25,000 IU, once daily were prescribed with regular follow-up at an interval of 1 month.