Mobile genetic elements (MGEs) represent a significant portion of the human genome, contributing to evolutionary processes through their mobility. This mobility, however, also introduces mutations. Some mutations induce exon skipping or premature truncation, resulting in non-functional or impaired proteins that contribute to various human diseases, including cancer. This study aims to explore MGE prevalence within cancer-associated genes in comparison to non-cancer-associated genes. We compiled gene lists for both categories, retrieved nucleotide sequences, and employed RepeatMasker analysis for MGE identification. Our analysis revealed a notable difference: cancer-associated genes exhibit higher MGE counts and greater sequence coverage by MGEs compared to non-cancer-associated genes. This heightened MGE presence may correlate with an increased susceptibility to significant DNA segment deletions/insertions, potentially elevating the risk of cancer initiation. Further investigation is essential to unveil the precise nature of these associations and their implications comprehensively.