Background: Oral squamous carcinoma cell is generally defined as an oral neoplastic disorder in the mouth. Hence, the OSCC originate from the epithelial lining, which is present in the oral cavity. Most cancers begin with lips and mouths in squamous cells, thin and flat cells that affect the lips and the oral cavity. So that’s why they are called squamous cell carcinomas. Objective: To evaluate the correlation between OSCC, paclitaxel and biochemical status. Methodology: 5.0 ml venous blood sample of 60 patients of OSCC treated with Paclitaxel and 50 Blood sample of Healthy individuals was taken in clotted gel vial from Oral and Maxillofacial department, Mayo hospital Lahore. Blood was further processed for the estimation of Reduce Glutathione (GSH), Catalase (CAT), Superoxide Dismutase (SOD), Malondialdehyde (MDA), Estimation of Nitric oxide (NO), Estimation of micronutrients (Vitamin A, Vitamin C and Vitamin E), Estimation of AOPPs, Estimation of AGEs, Liver Functions tests (LFTs), Lipid Profile, Estimation of urea and creatinine and Electrolytes concentration by flame photometer (Na+ and K+) by kit method.