Liver diseases as one of the fatal diseases worldwide, second most common cause of death. Cadmium (Cd) is a heavy metal that naturally occurs, and many methods have suggested that it may be hazardous to the liver. The current study's objective was to assess the potential hepatoprotective effects of Drynaria quercifolia rhizome extract using an animal model. Six rats were randomly assigned to each of the five groups: Group I received saline (0.5 ml/kg) as a normal control, Group II received cadmium chloride (3.5 mg/kg/IP/single dose) as a disease control, and Group III received cadmium chloride (3.5 mg/kg/IP/single dosage) intoxicated rats pretreated with rhizome extract of Drynaria quercifolia orally (300mg/kg) for 30 days, Group IV- Cadmium chloride intoxicated rats received standard drug silymarin (25 mg/kg), Rats in Group V were given an oral dose of Drynaria quercifolia rhizome extract (300mg/kg) for 30 days. The results of biochemical assays and histopathological studies revealed that the plant extract was found to have possible protective effect against the liver damage produced by cadmium chloride at a dosage level of 300 mg/kg, and the results were equivalent to those of the widely used drug silymarin and how well Drynaria quercifolia rhizome extract (L) works. Future opportunities of the plant would undoubtedly be numerous. Hence, it can be recommended therapeutically for treating liver disorders. To identify the hepatoprotective bioactive elements in plant extract, more investigation is needed.