Pulmonary surfactants, composed of lipids and proteins, play vital roles in lung physiology and mechanics. Exploiting their unique properties, such as their interaction with lung epithelium, surfactants have emerged as promising carriers for drug delivery to the lungs. This review explores the potential of pulmonary surfactants as drug delivery vehicles, focusing on leveraging endogenous systems within the lung for therapeutic intervention. Beginning with an overview of pulmonary surfactants and the importance of drug delivery to the lungs, the review highlights the need for innovative strategies to overcome barriers encountered in traditional pulmonary drug delivery approaches. By harnessing the inherent mechanisms of surfactant uptake and recycling, novel avenues for targeted and sustained drug delivery are elucidated. The objectives of this review encompass synthesizing current knowledge, evaluating preclinical and clinical evidence, and identifying future directions in the field. Through this exploration, the review aims to contribute to the advancement of pulmonary therapeutics and healthcare