Background: Chronic obstructive pulmonary disease (COPD) is a long term lung disease that is one of the leading causes of death globally. The prevalence of COPD and associated mortality rates are increasing, with major risk factors such as smoking, air pollution and occupational exposure to pollutants. In addition to its impact on the respiratory system, COPD is also associated with an increased risk of sarcopenia, a condition of progressive muscle degeneration associated with decreased muscle strength and mass. Sarcopenia in COPD patients can worsen quality of life, increase hospitalisation rates, and worsen prognosis. Although the prevalence of sarcopenia has been reported to increase as COPD severity increases, research results regarding the relationship between COPD severity and sarcopenia incidence are mixed. Objective: To analyse the relationship between the severity of COPD and the incidence of sarcopenia in patients in Indonesia, especially in Makassar, to clarify the relationship between these two conditions and contribute to improving the quality of management of COPD patients. Subjects and Methods: This study used an analytical observational design with a cross-sectional approach conducted at Dr Wahidin Sudirohusodo Hospital. The study population included all patients with a diagnosis of Chronic Obstructive Pulmonary Disease (COPD), with the sample consisting of patients who met the inclusion criteria based on spirometry results and informed consent, and had not taken corticosteroids in the past three months. The minimum sample size required was 52 patients, which was calculated using a statistical formula. Results: This study showed that of the 62 subjects with ages ranging from 45 to 82 years, the majority were 61-70 years old. Of these subjects, 54.8% were non-obese and 45.2% were obese. Sarcopenia was identified in 77.4% of the subjects, of which 18.8% were severe. Analysis showed a significant association between the degree of Chronic Obstructive Pulmonary Disease (COPD) and the incidence of sarcopenia; the incidence of sarcopenia was 100% in moderate to very severe COPD, while only 44% in mild COPD. The correlation between the degree of COPD and the degree of sarcopenia showed a very strong association (R=0.879), indicating that the more severe the COPD, the more severe the sarcopenia. Additional analyses found that age was significantly associated with sarcopenia at age >70 years, and the incidence of sarcopenia was higher in non-obese subjects than obese ones. Multivariate analysis confirmed that the degree of COPD was significantly associated with the degree of sarcopenia, while age showed no significant association. Conclusion: the majority of COPD subjects were in the mild stage, but sarcopenia was found in the majority of subjects. A significant association was identified between the severity of COPD and the incidence of sarcopenia, with a higher prevalence of sarcopenia in patients with moderate to very severe COPD than in mild COPD. There was a very strong association between increasing degrees of COPD and the severity of sarcopenia.