Nowadays, kidney dysfunction is a real public health problem. Unfortunately, information ontheprevalenceofthisdiseaseamongpeoplelivingwithHIVisnon-existent.Thisworkstudiesthe prevalence of renal dysfunction and associated risk factors among people living withHIV/AIDS,underantiretroviraltreatment,attheoutpatienttreatmentcenterofMakokou(CTA-MKK);intheNorth-EastofGabon. Thisiscross-sectionalanddescriptivestudyanalysisofpatientrecordconductedfromJanuaryto December 2022.It included all PLWHIV undergoing antiretroviral treatment and followedat the Makokou outpatient treatment center. Among these patients, at least one marker of renalimpairment (elevation of plasma creatinine, deterioration of the estimated glomerular filtrationrate (eGFR)) was diagnosed. The parameters analyzed were sociodemographic, clinical, andparaclinical.Statistical analyseswereperformedatthe95%level,andtheresultsweresignificantatp≤0.05. A total of 356 HIV-1 positive individuals participated in this study. With a mean age of 50.21years,18%ofHIV-positiveindividualswerediagnosedwithrenaldysfunction(95%CI:[0.14-0.22]). Univariate analyses and adjustment of the prevalence of renal dysfunction according tosociodemographic,clinicalandpara-clinicalcharacteristics,amongHIV-infectedpersonsattheMakokouCTA,indicatedthatfemalegender(adjustedOR=1.45;95%CI:[1.13;1.85] p=0.003),agerange≥61years(adjustedOR=0.46;95%CI[0.29;0.87]p=0.016),duration onATRtreatment(adjustedOR=0.023;95%CI:[0.004;0.126]p=0.000),overweight (adjustedOR=85.9;95%CI:[1.416;5214]p=0.034),viralload(adjustedOR=0.0038;95% CI[0.003;0.64]9=0.024),andsevereimmunedeficiency(adjustedOR=122.5;95%CI:[1.18 ;7584]p=0.022),wereidentifiedaspotentialsignificantriskfactorsforrenaldysfunctioninthe presentstudy. InordertopredictandmonitordiseaseseverityandriskstratificationamongPLWHIV,studiesonthe prevalence,molecularandclinicalepidemiologyofrenaldysfunctionare needed.