Background: Oral cancer is one of the most common cancers and it constitutes a major health problem, particularly in developing countries. It is one of the leading causes of death. Tobacco and alcohol consumption appears to be the major determinants of oral cancer. Various plants have been used in India for several decades for the therapy of oral cancer. All showed the plant's different mechanisms of action for the management of oral cancer and its related symptoms.Objective: The aim of this research article is to highlight the Pathway or mechanism of action and efficacy of various herbal plants in the management of Oral cancer. Method: The information for their research article was acquired by using Google Scholar and PubMed as search engines, as well as a number of publishers, including Springer Nature, Bentham Science, Taylor & Francis, and Elsevier. Result: Oral cancer-causing factors, types of cancer, sign or symptom of cancer, the treatments of cancer, and problems related to cancer treatments. The common therapies are given to patient’s chemotherapy, radiation therapy, immunotheand Quercetin) for a better future for cancer treatments