Nowadays, in the world, as well as in our country, the incidence of miscarriage is not decreasing, but is widespread. There are many known factors that can cause miscarriage: somatic diseases, gynecological diseases, as well as complicated obstetric history. There is evidence of a genetic predisposition to miscarriage, which includes polymorphism of genes that are responsible for the formation of connective tissue and the formation of inflammatory mediators. The age of a pregnant woman under 18 years and over 35 years is associated with an increase in the incidence of early pregnancy loss.