: Fresh Frozen Plasma (FFP) is a frozen plasma product that contains all clotting factors, especially the labile factors V and VIII: useful for clotting deficiencies other than Hemophilia A, VWD and hypofibrinogenemia. It is generally used in therapeutic plasmapheresis procedures as a replacement fluid to maintain intravascular volume. Objective: To evaluate the utilization of FFPs in relevance to their indications. Materials and Methods: Retrospective evaluation of FFPs issued in the Govt. General hospital, Ananthapuram from November 2019 to October 2023 to different departments for various indications. Results: During the four-year period from 2019 to 2023, a total of 1644 units of FFP were received by 756 patients for various indications into different departments. The department with the highest number of units of request was surgery with a total of 481 but according to the number of patients, department of Paediatrics stood before all accounting for 27.8%. Most common indication was for Surgery either prophylactic or therapeutic from surgery department, most relevant and appropriate request was from labour room of OBG department for APH/PPH while the most inappropriate request was found to be for Malnutrition/Anemia. Conclusion: Educational interventions and regular audits are necessary to prevent inappropriate usage of FFP in transfusions.