This in-depth review investigates the intricate interplay between oxidative stress, inflammation and infertility, placing specific emphasis on the crucial involvement of NF-kB gene mutation. The delicate equilibrium within these biological processes significantly influences reproductive health. The investigation covers the impact of oxidative stress on fertility, the inflammatory mechanisms contributing to reproductive dysfunction and the growing importance of NF-kB gene mutation in the realm of infertility. Comprehending the molecular connections between these elements is vital for unraveling the complexities of reproductive disorders. The review explores noteworthy discoveries, potential targets for therapeutic intervention and future directions for research, shedding light on the interwoven role of oxidative stress, inflammation and NF-kB gene mutation in the intricate landscape of infertility.