Oral cancer accounts for 3% of global malignancies. In India, oral potentially malignant disorders are the first noticeable signs observed in the oral cavity, with a prevalence rate ranging from 13.2% to 13.9%. The absence of diagnosis, limited knowledge, and rising tobacco use contribute to the advancement of these precancerous lesions into oral carcinoma. The prevalence of mortality and morbidity related to oral cancer in India has risen, highlighting the need for readily available diagnostic tools. A novel method in this context is the visually-enhanced lesion scope (VEL scope), a compact and portable handheld instrument that enables direct visualisation of the oral cavity. VEL scope has been reported to be ideal adjunctive diagnostic tool for mass screening and determining the optimal biopsy site during surgical procedures. A series of case reports is presented where VEL scope was employed as a supplementary diagnostic instrument to evaluate the precision of the device's diagnostic capabilities in various situations with a light on its limitations. A multidisciplinary approach is necessary to prevent the progression of Oral potentially malignant disorders like Oral submucous fibrosis, oral leukoplakia to malignancy. Autofluorescence-based imaging systems like VELscope have become increasingly popular in oral cancer screening due to their quick and noninvasive nature.