Hyperlipidemia is a major cause of heart disease and the atherosclerosis-associated condition such as coronary heart disease ischemic cerebrovascular disease and peripheral vascular disease. The present study was carried out to investigate antihyperlipidemic properties of ethanolic stem extract of Acalypha indica and Croton bonplandianus baill against hyperlipidemia induced by high fat diet (HFD) in wistar albino male rats. Wistar albino male rats were divided in 7 groups. Group I received normal diet. Group II- received high fat diet. Group III- received atorvastatin 10mg/kg served as standard drug. Group IV- received (200mg/kg, p.o.) ethanolic stem extract of Acalypha indica (ESAI). Group V- received (400mg/kg, p.o.) ESAI, Group VI- received (200mg/kg, p.o.) ethanolic stem extract of Croton bonplandianus baill (ESCBB) and Group VII- received (400mg/kg, p.o.) ethanolic stems extract of Croton bonplandianus baill (ESCBB). At the end of experiment The ESAI and ESCBB treatment and Atorvastatin drug significantly lower the body weight by the reduction in the LDL, VLDL levels and increase HDL levels. Oral administration of ethanolic stems extracts significantly reduced the cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins and significantly increased the HDL-cholesterol level as compared with high cholesterol diet induced hyperlipidemic animals.