Background: With the increasing prevalence of type 2 diabetes mellitus, there is continuous surge of self-management to prevent long term complications. Hence, the aim of this cross-sectional study is to determine the association between mental health, educational levels and their relationship with diabetes self-management among type 2 diabetes patients in Jazan region of Saudi Arabia. Methods: An observational cross-sectional study design was employed, with data collected through a structured, validated, self administered questionnaire. The instruments used included the Patient Health Questionnaire (PHQ-4) and the Diabetes Self-Management Questionnaire (DSMQ). The study's sample size was determined to be 445 diabetic patients. Data analysis was conducted using IBM SPSS Statistics software, incorporating both descriptive and inferential statistical methods. Results: The study included 445 participants, of whom 51.7% were female. Most participants were married (57.9%), fell within the age range of 36-55 years (43.4%), and had attained a university-level education (40.8%). In terms of self-management activities, the study revealed that 52.8% of participants never checked their blood sugar levels, and 34.7% occasionally missed planned physical activities. Additionally, 39.6% frequently missed taking their diabetes medication. The study also assessed psychological disorders among the participants, finding that 37.0% reported a lack of interest and pleasure in activities, and 33.0% struggled to control anxiety and worry. Furthermore, the results indicated a significant correlation between education level, duration of illness, and diabetes self management. Conclusions: The study identified a significant association between long-term diabetes, educational status, and self-management. In Jazan, Saudi Arabia, poor self-care behaviors among individuals with T2DM are prevalent due to inadequate dietary habits.