Background: Ultrasound imaging plays a crucial role in delivering high-quality obstetric care, serving purposes such as gender determination and assessing various parameters. Placenta is known to play a substantial part in fetal development and there is a keen interest in finding any association between placental location and neonatal gender but no consistent fallouts have been found. Aim: The study aims to explore the correlation between antenatal placental localization and neonatal gender in pregnant women during labor through the use of ultrasound. Patients and Methods: Conducted as a cross-sectional analytical study, this research delved into ultrasound findings in 179 pregnant patients within the gynecology department. The study employed a convenient sampling technique. Neonatal gender estimates were made based on placental location (anterior, posterior), and these estimates were then used to correlate with after-birth gender. By using version 21 of SPSS software, statistical analyses were performed, with a set significance level of P value less than 0.05. Results: Among 179 participants, a significant association was observed between neonatal gender and placental location. Male neonates were more prevalent (73.0%, p=0.001) in the posterior side of the placenta, while females exhibited a higher incidence (68.0%, p=0.001) in the anterior location. This association reached statistical significance with a p-value of less than 0.0001. Conclusion: In conclusion, the study establishes a notable correlation between placental localization and neonatal gender. Females tend to have mostly anterior placenta, whereas males are associated more with a posterior placenta