Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening conditions typically triggered by medications, characterized by widespread skin detachment and mucosal involvement. Prompt diagnosis and treatment are crucial for improving patient outcomes. The severity of these conditions can be assessed using the SCORTEN scale, which helps predict mortality risk. Case Illustration: We report the case of a 42-year-old female, Mrs. M, who developed erythematous lesions covering the body for less less than 10% of her body surface area (BSA) after being treated with sulfasalazine, cefotaxime, and levofloxacin. Her symptoms included mucosal involvement and a positive Nikolsky sign, indicative of SJS. The SCORTEN score calculated for this patient was 1/7, correlating with a 3,2% mortality risk. She was admitted to the emergency department and received supportive care at isolation room, including fluid management, wound dressing, and topical to systemic corticosteroids. Discussion: This case highlights the critical role of early identification and intervention in SJS/TEN, as timely discontinuation of the offending drug and the initiation of supportive therapy are vital for patient survival. The use of SCORTEN provided valuable prognostic information, guiding the intensity of the treatment approach. Despite the initial severity, the patient responded positively to the treatment regimen, with a gradual improvement in her condition and no significant long-term complications. Conclusion: This case underscores the importance of rapid diagnosis, immediate withdrawal of the causative agent, and comprehensive supportive care in managing SJS. The utilization of prognostic tools like SCORTEN can aid in tailoring the treatment approach and improving patient outcomes in such severe drug reactions.