PPAR γ (Peroxisome proliferator Activated Receptors gamma) has physiological response in body upon its activation through different agonists which can be fruitful for management of cancer. Using Molecular docking we designed suitable agonists which could be the possible pharmacophores for PPAR γ activation. Some ester derivatives of rhodanine are designed using Structural Activity Relationship Studies by V Life MDS Software package version 4.2 and synthesized by Schotten Bauman's Esterification reaction. In current work we synthesized five derivatives and are characterized by spectroscopic techniques that validate the correct synthesis of the compounds. Further evluated their effect on MCF7 cell lines for Anticancer Potential