Scientists have thoroughly studied numerous approaches to weight reduction, and some of them are being used among overweight or obese people. This includes diet, exercise, yoga, barometric surgery, intermittent fasting, etc. Despite the successes and failures of each approach, a one-size-fits-all approach may not be practical for individuals with regular daily routines who aim to shed excess weight to prevent future health issues. The downsides of some methods, such as dieting and intermittent fasting, include headache, dullness, and excessive cravings. The ease and practicality of these approaches for typical working individuals, along with the continuation of daily routine, are challenging. In the present case series, 21 participants (Ages 18 to 60 years) were willing to embark on a weight loss journey without significantly disrupting their normal lives. Each individual revealed their history, focusing on the cause of weight gain. Also, their unique Prakriti (Vata, Pitta, Kaph) and weight were assessed. Further, they have been given a customized combinatorial approach, which contains changes in their lifestyle, diet, and yoga practice, and they followed the recommended Dhauti technique as per Prakriti. After the follow-up, each case was assessed based on their BMI, body weight, and subjective psycho-physical changes. This Combinatorial Approach (Dhauti, Yoga, and Diet) yielded promising results for all individuals, leading to healthy weight loss with fewer challenges. Furthermore, subjective psychological status also improved.